Doer of "the Human Genome Project" is ready to "re-do it all"
[See posting at http://www.junkdna.com/new_citations.html ]
'Champion of "the Human Genome Project" does it again from scratch':
Venter, Launching New Company, Hopes to Synthesize Genome to Create Bacterium
NEW YORK, June 29 (GenomeWeb News) - Nearly four years after being shown the door at Celera Genomics and creating a family of nonprofits, Craig Venter has founded a new company that aims to create an organism from synthetically crafted and oriented genes.
The company, Synthetic Genomics, is in the process of building a "minimal genome" that can be inserted into the shell of a bacterium, in this case the 517-gene Mycoplasma genitalium, which scientists may eventually genetically engineer to perform specific industrial tasks.
... After designing and producing a synthetic chromosome ... the team plans to develop a proof of concept in either of two bio-energy applications: hydrogen or ethanol.
.... At a 2003 press conference announcing results from that research, Venter stressed that his team would not commercialize PCA, nor would he file patents on it. "We'd rather wait till the next stage when there's a clear-cut application: for instance if we have something that produces hydrogen that might hold some value"
posted by Dr. Andras J. Pellionisz at 4:49 PM
3 Comments:
Wow ! "something that produces hydrogen that might hold some value".... The understatement of the 21st Century. He is talking about a global impact by creating the first "protein-based nanotechnology miracle". When Craig Venter told the USA government that he'd finish "the Human Genome Project" cheaper, better, faster in the private sector, nobody believed him (and he/his Celera delivered what he promised). I am convinced that Craig Venter will pull it off again. And some more. The bacterium that he focuses on is one of the smallest genome and is very stingy on "non-coding" (formerly "junk") DNA. Yet, bacteria, while poor in "JunkDNA" still have some, e.g. the bacterium Venter picked has 8% (typically, bacteria have over 10% "junk" occasionally a huge amount, see table). Thus, this commentator expects that that precious little "junkDNA" in the "hydrogene producing bacterium" will actually catapult the understanding of the "regulatory" role of "JunkDNA", since it will be so much easier to focus on the critical little amount of 8%. Indeed, it has been known both that total elimination of "junk" kills the living system, as well as that Nanotechnologists (attempting to synthesize protein-based new materials) simply can not do without "regulatory DNA". Now the task is reduced to revealing what less than 50 kb information does! While at the 50th Anniversary Meeting in Montery 2002 Dr. Venter held the view that "JunkDNA" is just that (junk...) - one wonders if JunkDNA will be a stumbling block for Dr. Venter's spectacular project (possibly patenting the pollution-free global source of energy...) , or he will bring us to a much quicker revealing of how the fractal iterative genesis regulates the functioning of DNA.
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