"JunkDNA" (98.7% of DNA in human) is not "Junk" - requiring a generalization of the "Gene concept". On http://www.junkdna.com website news items are posted (some of them reproduced here from http://www.junkdna.com/new_citations.html ) - to be discussed. My "two cents" is FractoGene (see similar website and upcoming book), a geometrization that has received now experimental support for its first prediction.

Friday, June 10, 2005

Behavior of Junkies determined by JunkDNA?

[for full article, see http://www.junkdna.com/new_citations.html]

Rodent Social Behavior Encoded in Junk DNA

A discovery that may someday help to explain human social behavior and disorders such as autism has been made in a species of pudgy rodents by researchers funded, in part, by the National Institutes of Health’s (NIH) National Institute of Mental Health (NIMH) and National Center for Research Resources (NCRR).

The researchers traced social behavior traits, such as monogamy, to seeming glitches in DNA that determines when and where a gene turns on. The length of these repeating sequences — once dismissed as mere junk DNA — in the gene that codes for a key hormone receptor determined male-female relations and parenting behaviors in a species of voles. Drs. Larry Young and Elizabeth Hammock, Emory University, report on their findings in the mouse-like animals native to the American Midwest in the June 10, 2005 Science.

...“This research appears to have found one of those hotspots in the genome where small differences can have large functional impact,” explained Insel. “The Emory researchers found individual differences not in a protein-coding region, but in an area that determines a gene’s expression in the brain. This is an extraordinary example of research linking gene variation to brain receptors to behavior.”

...“It was considered junk DNA because it didn’t seem to have any function,” noted Hammock.

In addition to NIH, the research was also supported by the National Science Foundation.
NIMH and NCRR are part of the National Institutes of Health (NIH), the Federal Government's primary agency for biomedical and behavioral research. NIH is a component of the U.S. Department of Health and Human Services.

1 Comments:

Blogger Dr. Andras J. Pellionisz said...

This article in the highly reputable Science on research done with support of the most prestigeous NIH/NSF is a landmark with a colossal impact. Ever since both the human (2000) and the mouse (2002) genome were revealed, with 99% of their "protein coding" content virtually identical (homologue), and such "genes" amounting only 1.3% of the 3.2 Megabasis-long DNA sequence, some of us were certain that only our 30% (!) more "JunkDNA" makes us not only human - but creates an enormous range of diversity from one human individual to the next. ("Genetic Fingerprinting" is based on the fact that while the genes are identical, "JunkDNA" varies in each individual). FractoGene, with the mathematical generalization of the "geneconcept" accounts for the facts found (see also experimental support of the 1st prediction of FractoGene submitted for peer-review by M.J. Simons and A.J. Pellionisz on 27/4/2005, and the 2nd prediction coming out in the FractoGene BrowserBook by Pellionisz). While the "2nd prediction" will directly impact "microarray technology" (from an Algorithmic Mathematical & Information Technology viewpoint), the finding reported here will blow open the "social studies" of the human race. Leadership of USA Government Health Care System (NIH/NSF/NIMH) will no doubt re-vamp the funding system of "JunkDNA" R&D.

10:10 AM

 

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